Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant need for investigating the effects of treatment that is optimized for bilingual speakers with PPA. This stage 2 efficacy clinical trial seeks to establish the effects of culturally and linguistically tailored speech-language interventions administered to bilingual individuals with PPA. The overall aim of the intervention component of this study is to establish the relationships between the bilingual experience (e.g., how often each language is used, how strong each language is) and treatment response of bilinguals with PPA. Specifically, the investigators will evaluate the benefits of tailored speech-language intervention administered in both languages to bilingual individuals with PPA (60 individuals will be recruited). The investigators will conduct an assessment before treatment, after treatment and at two follow-ups (6 and 12-months post-treatment) in both languages. When possible, a structural scan of the brain (magnetic resonance image) will be collected before treatment in order to identify if brain regions implicated in bilingualism are associated with response to treatment. In addition to the intervention described herein, 30 bilingual individuals with PPA will be recruited to complete behavioral cognitive-linguistic testing and will not receive intervention. Results will provide important knowledge about the neural mechanisms of language re-learning and will address how specific characteristics of bilingualism influence cognitive reserve and linguistic resilience in PPA.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Healthy Volunteers: t
View:

• Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)

• Bilingual in Spanish and Catalan or bilingual in Spanish and English

• Different proficiency levels across languages are expected, any prior experience in both languages is acceptable

• Intervention study: Score of 15 or higher on the Mini-Mental State Examination

• Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination

Locations
United States
Texas
University of Texas at Austin
RECRUITING
Austin
Other Locations
Spain
Hospital Clínic de Barcelona
NOT_YET_RECRUITING
Barcelona
Hospital de la Santa Creu i Sant Pau
RECRUITING
Barcelona
Contact Information
Primary
Camille Wagner Rodríguez, M.S., CCC-SLP
wagner.camille@austin.utexas.edu
512-471-4119
Backup
Sonia-Karin Marqués-Kiderle
smarques@santpau.cat
Time Frame
Start Date: 2023-05-01
Estimated Completion Date: 2027-11-30
Participants
Target number of participants: 60
Treatments
Experimental: Lexical Retrieval Training
Naming intervention for individuals with logopenic or semantic variant PPA.
Experimental: Video Implemented Script Training for Aphasia
Script training intervention for individuals with nonfluent/agrammatic PPA.
Sponsors
Collaborators: Hospital Clinic of Barcelona, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Leads: University of Texas at Austin

This content was sourced from clinicaltrials.gov